She gained popularity through her leading roles in television dramas Autumn in My Heart (2000), All In (2003), Full House (2004), That Winter, the Wind Blows (2013) and Descendants of the Sun (2016) which achieved pan-Asia success.
She has also starred in films Hwang Jin Yi (2007), The Grandmaster (2013), My Brilliant Life (2014) and The Queens (2015).
Song reunited with the writer and director of Worlds Within in That Winter, the Wind Blows, a 2013 remake of 2002 Japanese drama Ai Nante Irane Yo, Natsu ("I Don't Need Love, Summer").
She played a blind heiress in the melodrama, opposite a con man pretending to be her long-lost brother (played by Jo In-sung).
She said that after receiving a notification from the National Tax Service, she paid the full amount with additional fines in the amount of ₩3.8 billion ( A representative from Song's agency said, "Because Song has travelled extensively for work, she has become aware of how important it is for tourists to be able to read information in their own language.” So, Song in collaboration with professor Seo Kyung-duk of Sungshin Women's University have decided to donate brochure or information in Korean to various historic Korean sites, art galleries and museums in the world.
Professor Seo praised Song who is supporting her country quietly.
Song then played a documentary filmmaker who finds the strength to forgive the 17-year-old boy who killed her fiancé but instead of redemption finds only greater tragedy in A Reason to Live (Korean title: Today), which after several delays was released in October 2011.She would continue to appear in a string of various dramas and sitcoms, notably Soonpoong Clinic.But it wasn't until the KBS drama Autumn in My Heart in 2000 with Song Seung-heon and Won Bin that she rose to fame in Korea and throughout Asia.That Winter, the Wind Blows placed number one in its timeslot during most of its run, and Song and Jo were praised for their performances.In 2014, Song reunited with Kang Dong-won in My Brilliant Life, E J-yong's film adaptation of Kim Aeran's bestselling novel My Palpitating Life about a couple who watched their son suffering from progeria grow prematurely old.In 2016, Song starred in the mega-hit romantic comedy series Descendants of the Sun, an intense drama about an army captain (played by Song Joong-ki) and a surgeon who fall in love while working amidst disaster-torn areas.